Due Fratelli is a “tragedy in fifty-three days” made up of short sequences marked by the passing of days and hours as in a diary. Lev is the younger brother, who was forced by life to do the head of household: he is a boy of exaggerated aggressiveness who hides many wounds and an incredible need to be loved. Boris is the older brother, who sees in Lev the only point of reference. He is a "pure", suffering from mild mental issues, obsessed by order, respect for rules and cleanliness. With his charge of grotesque irony he can often defuse the situation more tense and dramatic with Erica, a girl who is weak and rebellious that shares with brothers the dilapidated apartment.
Erica and Lev love and separate each other, injure themselves and run after each other, without ever meeting. The girl will inevitably become the source of nuisance and conflict between the "Two Brothers", coming to know, understand, and eventually disrupt both. The common denominator of the three boys is the unspoken need of love, the desire for happiness that basically they do not believe to be made for them.